From Scranton, Wilkes-Barre & North:
Take Route I-81 South
Merge onto US-22E via Exit 67 toward PA-230 / Cameron Street
Turn right onto Herr Street
Turn left onto N 7th Street
Keep left at the fork to continue on N 7th Street
Turn right onto Forster Street
Forster Street becomes M Harvey Taylor Memorial Bridge
Take the Erford Road ramp
Turn right onto Erford Road
Erford Road becomes N. 12th Street
525 N. 12th Street is on the right, just past Lemoyne Drive

From Carlisle, Chambersburg:
Take Route I-81 North to Exit 61 (Wertzville Road/PA 944)
Turn right onto Wertzville Road/PA944
Turn right onto E Penn Drive
(E Penn Drive becomes Center Street)
Turn left onto Poplar Church Road
Turn  onto Erford Road
Erford Road becomes N. 12th Street
525 N. 12th Street is on the right, just past Lemoyne Drive

From York:
Take Route I-83 North to Exit 42 toward Lemoyne
Make a slight right onto S. 3rd Street
Turn left onto Market Street
Turn right onto N. 12th Street
525 N. 12th Street is on the left, approx. 0.3 miles past Indiana Circle

From Philadelphia:
Take the PA Turnpike West to Exit 236
Take Route 15 North into Camp Hill (6 traffic lights)
Turn left on 21st Street
(21st Street becomes Poplar Church Road)
Turn right onto Erford Road
Erford Road becomes N. 12th Street
525 N. 12th Street is on the right, just past Lemoyne Drive

From Pittsburgh:
Take the PA Turnpike East to Exit 236
Take Route 15 North into Camp Hill (6 traffic lights)
Turn left on 21st Street
(21st Street becomes Poplar Church Road)
Turn right onto Erford Road
Erford Road becomes N. 12th Street 
525 N. 12th Street is on the right, just past Lemoyne Drive